Abstract
Both cis- and trans-5-(aminomethyl)-3-aryldihydrofuran-2(3H)-one hydrochloride salts (9 and 10) were synthesized efficiently in a 5-step sequence from arylacetic acids. Both compounds were found to be irreversible inactivators of monoamine oxidase B. These compounds constitute the first members of a new class of monoamine oxidase inactivators.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cattle
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Furans / chemical synthesis*
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Furans / pharmacology
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Kinetics
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Lactones / chemical synthesis*
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Lactones / pharmacology
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Liver / enzymology
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Methylamines / chemical synthesis
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Methylamines / pharmacology
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Molecular Structure
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Monoamine Oxidase Inhibitors / chemical synthesis*
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Monoamine Oxidase Inhibitors / pharmacology
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Stereoisomerism
Substances
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Furans
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Lactones
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Methylamines
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Monoamine Oxidase Inhibitors